Influenza virus particle in soft painterly colours on a pastel green background. Flu viruses are covered by spikes of Haemagglutinin (slender knob-like projections) and Neuraminidase (the squarish looking projections), hence the H and N names, such as H5N1. Flu viruses have a segmented genome which can get jumbled up during replication (gene mixing). This allows different strains to easily form from existing types. Flu occurs in seasonal epidemics and periodically as major pandemics.